| NCT | Title | Status | Study Type | Location | Sponsors | Start Date-End Date |
|---|---|---|---|---|---|---|
| NCT00001248 | Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS) | Recruiting | Observational | National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda Maryland 20892 United States | National Institutes of Health Clinical Center (CC) | July 23, 1992 - N/A |
| NCT00716066 | Autologous Peripheral Blood Stem Cell Transplant for Neurologic Autoimmune Diseases | Recruiting | Interventional | Colorado Blood Cancer Institute Denver Colorado 80218 United States | Fred Hutchinson Cancer Research Center | June 2008 - December 1, 2027 |
| NCT00794352 | Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System | Recruiting | Observational | National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda Maryland 20892 United States | National Institutes of Health Clinical Center (CC) | October 1, 2008 - N/A |
| NCT00919217 | Exploratory Study on the Timing of Multiple Sclerosis (MS) Symptoms | Recruiting | Observational | University of Louisville (recruiting nationwide) Louisville Kentucky 40292 United States | University of Louisville | August 2008 - December 2022 |
| NCT01018537 | NARCOMS Registry: A Multiple Sclerosis Registry | Recruiting | Observational [Patient Registry] | Washington University School of Medicine Saint Louis Missouri 63110 United States | Washington University School of Medicine | January 1996 - December 2050 |
| NCT01285479 | The Gilenya Pregnancy Registry | Recruiting | Observational | Novartis Investigative Site Fort Lauderdale Florida 33308 United States | Novartis | October 15, 2011 - January 2, 2031 |
| NCT01353547 | Genes and Environment in Multiple Sclerosis | Recruiting | Observational | National Institute of Neurological Disorders and Stroke Bethesda Maryland 15213 United States | Columbia University | October 1, 2017 - October 2040 |
| NCT01466114 | Estriol Treatment in Multiple Sclerosis (MS): Effect on Cognition | Recruiting | Interventional | University of California Los Angeles Los Angeles California 90095 United States | University of California, Los Angeles | October 2011 - April 2022 |
| NCT01703429 | Complementary and Alternative Care in Multiple Sclerosis | Recruiting | Observational | Bastyr University Clinical Research Center Kenmore Washington 98028 United States | Bastyr University | June 2012 - June 2030 |
| NCT01730131 | Natural History Study of Progressive Multifocal Leukoencephalopathy (PML) | Recruiting | Observational | National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda Maryland 20892 United States | National Institutes of Health Clinical Center (CC) | November 8, 2012 - January 1, 2027 |
| NCT01838174 | A Trial of Neuroprotection With ACTH in Acute Optic Neuritis | Recruiting | Interventional | University of Colorado Denver Aurora Colorado 80045 United States | University of Colorado, Denver | May 2013 - May 2021 |
| NCT01892722 | Safety and Efficacy of Fingolimod in Pediatric Patients With Multiple Sclerosis | Recruiting | Interventional | Novartis Investigative Site Birmingham Alabama 35294 United States | Novartis | July 26, 2013 - December 15, 2028 |
| NCT01909492 | Relaxin in Multiple Sclerosis (MS) | Recruiting | Observational | Providence MS Center Portland Oregon 97225 United States | Providence Health & Services | September 20, 2013 - September 2022 |
| NCT01911767 | Biogen Multiple Sclerosis Pregnancy Exposure Registry | Recruiting | Observational [Patient Registry] | Research Site Boston Massachusetts 2115 United States | Biogen | October 30, 2013 - December 31, 2028 |
| NCT01931644 | At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions | Recruiting | Observational | Sanguine Biosciences Los Angeles California 91403 United States | Sanguine Biosciences | July 2013 - December 2040 |
| NCT01970410 | Sub-Study: Analysis of JCV Antibody Index in MS Patients Treated With Teriflunomide - SWITCH-JCV | Recruiting | Interventional | Phoenix Neurological Associates, Ltd Phoenix Arizona 85018 United States | Providence Health & Services | October 2013 - December 1, 2021 |
| NCT02057159 | A Study of NeuroVax™, a Therapeutic TCR Peptide Vaccine for SPMS of Multiple Sclerosis | Recruiting | Interventional | CRO San Diego California 92129 United States | Immune Response BioPharma, Inc. | March 9, 2020 - March 9, 2023 |
| NCT02149706 | A Study of NeuroVax™, a Novel Therapeutic TCR Peptide Vaccine for SPMS of Multiple Sclerosis | Not yet recruiting | Interventional | CRO San Diego California 92129 United States | Immune Response BioPharma, Inc. | March 9, 2020 - March 9, 2022 |
| NCT02200718 | A Study of NeuroVax™, a Novel Therapeutic TCR Peptide Vaccine for Pediatric Multiple Sclerosis | Not yet recruiting | Interventional | CRO San Diego California 92129 United States | Immune Response BioPharma, Inc. | December 31, 2020 - November 9, 2024 |
| NCT02402426 | Brain Health Registry: An Online Registry to Identify and Assess Subjects for Brain Research | Recruiting | Observational [Patient Registry] | BrainHealthRegistry.org San Francisco California 94143 United States | University of California, San Francisco | September 2013 - September 2028 |
| NCT02454907 | The Use of Technology to Improve MS Clinical Trials and Patient Care | Recruiting | Interventional | Johns Hopkins University Baltimore Maryland 21287 United States | Johns Hopkins University | July 31, 2018 - May 31, 2024 |
| NCT02486562 | iConquerMS™ - A Patient-Powered Research Network for Multiple Sclerosis | Recruiting | Observational | Accelerated Cure Project Waltham Massachusetts 02451 United States | Accelerated Cure Project for Multiple Sclerosis | November 2014 - N/A |
| NCT02496416 | Comparison of Two Physical Activity Interventions in Individuals With Multiple Sclerosis | Recruiting | Interventional | Kessler Foundation East Hanover New Jersey 07936 United States | Kessler Foundation | August 2016 - June 2021 |
| NCT02521311 | Assessment of Clemastine Fumarate as a Remyelinating Agent in Acute Optic Neuritis (ReCOVER) | Recruiting | Interventional | University of California San Francisco San Francisco California 94158 United States | University of California, San Francisco | August 2016 - August 2022 |
| NCT02544373 | CPAP to Treat Cognitive Dysfunction in MS | Recruiting | Interventional | University of Michigan Medical Center Ann Arbor Michigan 48109 United States | University of Michigan | November 12, 2015 - July 31, 2021 |
| NCT02649985 | Microglial Activation Positron Emission Tomography (PET) Brain Imaging in Multiple Sclerosis and Alzheimer's Disease | Recruiting | Interventional | Partners MS Center, 60 Fenwood Road Boston Massachusetts 02115 United States | Brigham and Women's Hospital | May 2, 2016 - December 31, 2021 |
| NCT02659956 | Pathological Basis of MRI Signal Changes in Multiple Sclerosis | Recruiting | Observational | National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda Maryland 20892 United States | National Institutes of Health Clinical Center (CC) | April 7, 2016 - February 26, 2080 |
| NCT02740361 | Online Program to Reduce Depression in MS | Recruiting | Interventional | Cedars-Sinai Medical Center Los Angeles California 90048 United States | Charite University, Berlin, Germany | February 15, 2017 - December 31, 2021 |
| NCT02784210 | Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques | Recruiting | Interventional | National Institutes of Health Clinical Center Bethesda Maryland 20892 United States | National Institutes of Health Clinical Center (CC) | October 5, 2016 - April 30, 2022 |
| NCT02795052 | Neurologic Stem Cell Treatment Study | Recruiting | Interventional | MD Stem Cells Westport Connecticut 06880 United States | MD Stem Cells | June 2016 - June 2023 |
| NCT02994121 | Prospective Investigation of Multiple Sclerosis in the Three Rivers Region | Recruiting | Observational | University of Pittsburgh Pittsburgh Pennsylvania 15260 United States | University of Pittsburgh | December 2016 - January 2047 |
| NCT03046251 | Natalizumab in Preventing Post-partum Relapses in Multiple Sclerosis | Recruiting | Interventional | SUNY Buffalo Buffalo New York 14203 United States | State University of New York at Buffalo | August 2015 - N/A |
| NCT03049969 | Cognitive Remediation Augmented With Transcranial Direct Current Stimulation (tDCS) | Recruiting | Interventional | New York University Medical Center New York New York 10016 United States | NYU Langone Health | February 7, 2017 - December 2021 |
| NCT03057652 | Algorithmic-Based Evaluation and Treatment Approach for Robotic Gait Training | Recruiting | Interventional | TIRR Memorial Hermann Houston Texas 77030 United States | The University of Texas Health Science Center, Houston | March 2016 - December 2022 |
| NCT03109288 | Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS) | Recruiting | Interventional | National Institutes of Health Clinical Center Bethesda Maryland 20892 United States | National Institutes of Health Clinical Center (CC) | August 11, 2017 - January 1, 2029 |
| NCT03110315 | A Study of Suvorexant in Patients With Multiple Sclerosis Fatigue and Insomnia | Recruiting | Interventional | EvergreenHealth Multiple Sclerosis Center Kirkland Washington 98034 United States | EvergreenHealth | March 28, 2017 - March 31, 2022 |
| NCT03117881 | Tele-Exercise and Multiple Sclerosis | Recruiting | Interventional | Upstream Rehabilitation Inc. Athens Alabama 35613 United States | University of Alabama at Birmingham | January 8, 2018 - January 31, 2023 |
| NCT03135327 | Clinical Applications of Advanced Ophthalmic Imaging | Recruiting | Interventional | Bascom Palmer Eye Institute Miami Florida 33136 United States | University of Miami | January 1, 2007 - December 31, 2025 |
| NCT03161028 | Lipoic Acid for Progressive Multiple Sclerosis (MS) | Recruiting | Interventional | University of Alabama at Birmingham Birmingham Alabama 35294 United States | VA Office of Research and Development | July 1, 2018 - August 31, 2023 |
| NCT03166930 | Evaluation of a Spasticity Management Program for People With Multiple Sclerosis | Recruiting | Interventional | VA Portland Health Care System, Portland, OR Portland Oregon 97239 United States | VA Office of Research and Development | January 1, 2018 - December 31, 2021 |
| NCT03174379 | A Study to Analyze the Effect of Acupuncture on Mobility And Quality of Life in Multiple Sclerosis | Recruiting | Interventional | New York University School of Medicine New York New York 10016 United States | NYU Langone Health | June 5, 2017 - December 2021 |
| NCT03198351 | An Observational Study on Teriflunomide-exposed Pregnancies | Recruiting | Observational [Patient Registry] | Investigator San Diego California 92093 United States | Sanofi | April 25, 2013 - December 1, 2022 |
| NCT03207464 | Molecular Imaging of Norepinephrine Transporter (NET) Using [C-11]Methylreboxetine PET in Multiple Sclerosis | Recruiting | Interventional | Partners MS Center, 60 Fenwood Road Boston Massachusetts 02115 United States | Brigham and Women's Hospital | October 10, 2017 - December 31, 2021 |
| NCT03233646 | OCTA in Mild Cognitive Impairment and Alzheimer's Disease | Recruiting | Interventional | Duke University Medical Center Durham North Carolina 27705 United States | Duke University | July 20, 2017 - December 31, 2021 |
| NCT03283826 | Phase 1/2 Study to Evaluate the Safety and Efficacy of ATA188 in Subjects With Progressive Multiple Sclerosis | Recruiting | Interventional | Mayo Clinic Scottsdale Arizona 85259-5452 United States | Atara Biotherapeutics | October 19, 2017 - February 2026 |
| NCT03319771 | Exercise and Learning and Memory in Multiple Sclerosis | Recruiting | Interventional | University of Alabama at Birmingham Birmingham Alabama 35294-0104 United States | University of Alabama at Birmingham | December 1, 2018 - November 30, 2021 |
| NCT03322982 | Low Fat Diet for Fatigue in MS | Recruiting | Interventional | Oregon Health Science University Portland Oregon 97239 United States | Oregon Health and Science University | August 15, 2018 - March 31, 2022 |
| NCT03423121 | A Trial of Bile Acid Supplementation in Patients With Multiple Sclerosis | Recruiting | Interventional | Johns Hopkins University Baltimore Maryland 21287 United States | Johns Hopkins University | June 19, 2018 - June 2021 |
| NCT03424733 | Evaluating the Use of Prednisone to Decrease Pegylated Interferon Beta-1a Side Effects | Recruiting | Interventional | Holy Name Medical Center Teaneck New Jersey 07666 United States | Holy Name Medical Center, Inc. | September 25, 2017 - May 31, 2020 |
| NCT03453125 | Improving Learning in Hispanics With TBI or MS | Recruiting | Interventional | Kessler Foundation East Hanover New Jersey 07936 United States | Kessler Foundation | September 25, 2013 - September 30, 2020 |
| NCT03468868 | Comparative Effectiveness Study Telerehab Versus Conventional | Recruiting | Interventional | The Tanner Center for Multiple Sclerosis Birmingham Alabama 35209 United States | Shepherd Center, Atlanta GA | July 23, 2018 - January 31, 2022 |
| NCT03490240 | Project BIPAMS: Behavioral Intervention for Physical Activity in Multiple Sclerosis | Recruiting | Interventional | Exercise Neuroscience Research Lab Birmingham Alabama 35233 United States | University of Alabama at Birmingham | March 1, 2018 - July 2022 |
| NCT03498131 | Melatonin in Patients With Multiple Sclerosis (MS). | Recruiting | Interventional | Providence MS Center Portland Oregon 97225 United States | Providence Health & Services | May 9, 2018 - March 2022 |
| NCT03500328 | Traditional Versus Early Aggressive Therapy for Multiple Sclerosis Trial | Recruiting | Interventional | University of Alabama at Birmingham Birmingham Alabama 35233 United States | Johns Hopkins University | May 2, 2018 - August 1, 2024 |
| NCT03521557 | Gaze and Postural Stability in Multiple Sclerosis | Recruiting | Interventional | University of Utah Salt Lake City Utah 84108 United States | University of Utah | May 29, 2018 - September 30, 2020 |
| NCT03523858 | A Study to Evaluate Ocrelizumab Treatment in Participants With Progressive Multiple Sclerosis | Recruiting | Interventional | MS Center of California Laguna Hills California 92653 United States | Hoffmann-La Roche | May 28, 2018 - June 26, 2025 |
| NCT03535298 | Determining the Effectiveness of earLy Intensive Versus Escalation Approaches for RRMS | Recruiting | Interventional | University of Colorado-Anschutz Medical Campus Aurora Colorado 80045 United States | The Cleveland Clinic | January 3, 2019 - September 2026 |
| NCT03536299 | Measurement and Training of Dual-Task of Gait in Persons With Multiple Sclerosis | Recruiting | Interventional | Texas Woman's University Institute of Health Sciences - Houston Center Houston Texas 77030 United States | Texas Woman's University | May 31, 2018 - May 31, 2020 |
| NCT03536559 | Nanocrystalline Gold to Treat Remyelination Failure in Chronic Optic Neuropathy In Multiple Sclerosis | Recruiting | Interventional | Johns Hopkins University Baltimore Maryland 21287 United States | Clene Nanomedicine | November 23, 2018 - September 2022 |
| NCT03539094 | Intermittent Fasting in Multiple Sclerosis | Recruiting | Interventional | Washington University in St Louis Saint Louis Missouri 63110 United States | Washington University School of Medicine | January 1, 2018 - December 31, 2021 |
| NCT03550170 | Fatigue Management Programs for People With MS | Recruiting | Interventional | University of Illinois at Chicago Chicago Illinois 60612 United States | Case Western Reserve University | March 1, 2019 - December 31, 2021 |
| NCT03551665 | Protective Stepping & MS | Recruiting | Interventional | Phoenix VA Health Care System, Phoenix, AZ Phoenix Arizona 85012 United States | VA Office of Research and Development | February 22, 2019 - September 1, 2023 |
| NCT03564496 | Assessment of tDCS-Induced Neuronal Responses in Multiple Sclerosis (MS) With Advanced MRI | Recruiting | Interventional | New York University School of Medicine New York New York 10016 United States | NYU Langone Health | July 9, 2018 - December 2021 |
| NCT03586986 | Risk Factors in Early Multiple Sclerosis | Recruiting | Observational | University of Colorado Anschutz Medical Campus Aurora Colorado 80045 United States | University of Colorado, Denver | July 26, 2018 - May 30, 2022 |
| NCT03621761 | Cognitive Behavioral Therapy, Modafinil, or Both for Multiple Sclerosis Fatigue | Recruiting | Interventional | The University of Michigan Ann Arbor Michigan 48109 United States | University of Michigan | November 15, 2018 - December 2021 |
| NCT03623243 | Safety and Tolerability of Conversion From Oral, Injectable, or Infusion Disease Modifying Therapies to Dose-titrated Oral Siponimod (Mayzent) in Advancing RMS Patients. | Recruiting | Interventional | Novartis Investigative Site Birmingham Alabama 35209 United States | Novartis | February 14, 2019 - January 12, 2022 |
| NCT03650114 | Long-term Safety, Tolerability and Effectiveness Study of Ofatumumab in Patients With Relapsing MS | Recruiting | Interventional | Novartis Investigative Site Birmingham Alabama 35233-0271 United States | Novartis | November 22, 2018 - October 3, 2028 |
| NCT03653390 | A Community Wellness Program for Adults Living With Long-term Physical Disability | Recruiting | Interventional | University of Washington Seattle Washington 98195 United States | University of Washington | January 31, 2019 - March 31, 2023 |
| NCT03658668 | Study of the Combined Effect of Transcranial Direct Current Stimulation (tDCS) and Physical Activity on Gait and Functional Mobility in Participants With Multiple Sclerosis | Recruiting | Interventional | New York University School of Medicine New York New York 10016 United States | NYU Langone Health | October 3, 2018 - December 2021 |
| NCT03677440 | Exercise Training Effects on Cognition and Brain Function in Multiple Sclerosis: Project EXACT | Recruiting | Interventional | Kessler Foundation West Orange New Jersey 07052 United States | Kessler Foundation | February 5, 2019 - September 30, 2023 |
| NCT03698149 | ECoG BMI for Motor and Speech Control | Recruiting | Interventional | University of California San Francisco San Francisco California 94158 United States | University of California, San Francisco | November 9, 2018 - August 15, 2030 |
| NCT03735654 | Multi-joint Muscle Fatigability and Gait Performance in People With Multiple Sclerosis | Not yet recruiting | Observational | Washington DC VA Medical Center Washington District of Columbia 20422 United States | Washington D.C. Veterans Affairs Medical Center | November 15, 2018 - October 1, 2021 |
| NCT03735823 | IL-11 in the Development of Multiple Sclerosis | Recruiting | Observational [Patient Registry] | Thomas Jefferson University Philadelphia Pennsylvania 19446 United States | Thomas Jefferson University | June 1, 2018 - May 31, 2023 |
| NCT03752307 | Safety and Tolerability of ISX (Isoxsuprine HCL) in MS Relapses | Recruiting | Interventional | University of New Mexico MS Specialty Clinic Albuquerque New Mexico 87106 United States | University of New Mexico | February 15, 2019 - December 1, 2020 |
| NCT03759522 | Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714. | Recruiting | Interventional | University of Alabama at Birmingham Medical Center Birmingham Alabama 35294 United States | University of Alabama at Birmingham | February 3, 2019 - November 1, 2021 |
| NCT03782246 | MBCT and CBT for Chronic Pain in Multiple Sclerosis | Recruiting | Interventional | UW Medicine Multiple Sclerosis Center Seattle Washington 98195 United States | University of Washington | November 28, 2018 - August 1, 2022 |
| NCT03797378 | Movement-2-Music: Lakeshore Examination of Activity, Disability, and Exercise Response Study | Recruiting | Interventional | UAB/Lakeshore Research Collaborative Birmingham Alabama 35209 United States | University of Alabama at Birmingham | August 9, 2019 - September 30, 2023 |
| NCT03804047 | KITAMS: Kinesio Tape and Physical Function in Persons With Multiples Sclerosis | Recruiting | Interventional | Department of Kinesiology and Physical Education. Northern Illinois University DeKalb Illinois 60115 United States | Northern Illinois University | January 1, 2019 - December 31, 2021 |
| NCT03816345 | Nivolumab in Treating Patients With Autoimmune Disorders and Advanced, Metastatic, or Unresectable Cancer | Recruiting | Interventional | Stanford Cancer Institute Palo Alto Palo Alto California 94304 United States | National Cancer Institute (NCI) | April 4, 2019 - August 31, 2022 |
| NCT03824938 | Aspirin for Exercise in Multiple Sclerosis (ASPIRE) | Recruiting | Interventional | Columbia University Irving Medical Center New York New York 10032 United States | Columbia University | April 30, 2019 - January 2022 |
| NCT03838770 | tDCS for the Management of Multiple Sclerosis Related Fatigue | Recruiting | Interventional | NYU Langone Health New York New York 10016 United States | NYU Langone Health | April 4, 2019 - October 1, 2021 |
| NCT03869879 | Mobility Rehab, a Therapist-assisted System for Gait Rehabilitation | Recruiting | Interventional | Northwest Rehabilitation Associate Salem Oregon 97302 United States | Oregon Health and Science University | July 24, 2019 - May 30, 2021 |
| NCT03870763 | Study to Evaluate the Efficacy and Safety of Dimethyl Fumarate (Tecfidera) and Peginterferon Beta-1a (Plegridy) for the Treatment of Relapsing-Remitting Multiple Sclerosis in Pediatric Participants | Recruiting | Interventional | Research Site Raleigh North Carolina 27607 United States | Biogen | March 19, 2019 - November 30, 2021 |
| NCT03926637 | Feasibility of the Multiple Sclerosis Performance Test in Participants With Multiple Sclerosis | Recruiting | Observational | Research Site Berkeley California 94705 United States | Biogen | June 17, 2019 - February 1, 2023 |
| NCT03933202 | A Study of Suboptimally Controlled Participants Previously Taking Oral or Infusion DMDs for RMS (MASTER-2) | Recruiting | Observational | North Central Neurology Associates, P.C. Cullman Alabama 35058 United States | EMD Serono | July 22, 2019 - November 15, 2026 |
| NCT03933215 | A Study of Suboptimally Controlled Participants Previously Taking Injectable DMDs for RMS (CLICK-MS) | Recruiting | Observational | North Central Neurology Associates, P.C. Cullman Alabama 35058 United States | EMD Serono | May 21, 2019 - December 12, 2025 |
| NCT03942952 | PEDIATRIC SONICS: Pediatric Study of Neuropsychology and Imaging in CNS Demyelinating Syndromes. | Recruiting | Observational | University Texas Southwestern Dallas Texas 75390 United States | University of Texas Southwestern Medical Center | October 22, 2019 - May 31, 2024 |
| NCT03944447 | Outcomes Mandate National Integration With Cannabis as Medicine for Prevention and Treatment of COVID-19 | Recruiting | Interventional | OMNI Medical Services Boca Raton Florida 33433 United States | OMNI Medical Services, LLC | December 1, 2018 - December 31, 2025 |
| NCT03958877 | A Study to Evaluate the Safety, Tolerability, and Efficacy of BIIB017 (Peginterferon Beta-1a) in Pediatric Participants for the Treatment of Relapsing-Remitting Multiple Sclerosis | Recruiting | Interventional | Research Site La Jolla California 92024 United States | Biogen | October 18, 2019 - March 31, 2023 |
| NCT03963375 | Cladribine Tablets: Collaborative Study to Evaluate Impact On Central Nervous System Biomarkers in Multiple Sclerosis | Recruiting | Interventional | Washington University School of Medicine Saint Louis Missouri 63110 United States | Washington University School of Medicine | October 28, 2019 - June 2023 |
| NCT03969927 | User-friendliness of a Portable Driving Simulator | Recruiting | Interventional | Abiodun Akinwuntan Kansas City Kansas 66160-8500 United States | University of Kansas Medical Center | August 28, 2019 - June 30, 2022 |
| NCT03972306 | A Study To Investigate The Pharmacokinetics, Safety, And Tolerability Of Subcutaneous Ocrelizumab Administration In Participants With Multiple Sclerosis | Recruiting | Interventional | University of Colorado; Anschutz Medical Campus Department of Neurology Aurora Colorado 80045 United States | Hoffmann-La Roche | August 12, 2019 - August 31, 2026 |
| NCT03983252 | Effect of Alemtuzumab on Microglial Activation Positron Emission Tomography (PET) in Multiple Sclerosis | Not yet recruiting | Interventional | Partners MS Center, 60 Fenwood Road Boston Massachusetts 02115 United States | Brigham and Women's Hospital | July 2019 - May 1, 2024 |
| NCT03983681 | Evaluation of a Theory-Driven Manualized Approach to Improving New Learning and Memory in MS | Recruiting | Interventional | Kessler Foundation East Hanover New Jersey 07936 United States | Kessler Foundation | September 26, 2019 - March 31, 2024 |
| NCT03993171 | 31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Multiple Sclerosis. | Recruiting | Interventional | University of Texas Southwestern Dallas Texas 75390 United States | Clene Nanomedicine | December 19, 2019 - July 2021 |
| NCT04002102 | Open-Label Placebos to Treat Fatigue in Multiple Sclerosis | Recruiting | Interventional | Tanner Foundation Birmingham Alabama 35209 United States | University of Alabama at Birmingham | February 17, 2020 - August 1, 2023 |
| NCT04002934 | Bazedoxifene Acetate as a Remyelinating Agent in Multiple Sclerosis | Recruiting | Interventional | Weill Institute for Neurosciences, University of California, San Francisco San Francisco California 94158 United States | University of California, San Francisco | September 10, 2019 - August 31, 2022 |
| NCT04009005 | Clinically Isolated Syndrome and Relapsing-Remitting Multiple Sclerosis | Recruiting | Interventional | University of Iowa Iowa City Iowa 52246 United States | University of Iowa | May 1, 2020 - January 1, 2027 |
| NCT04016844 | tDCS and Glucose Uptake in Leg Muscles | Recruiting | Interventional | University of Iowa Iowa City Iowa 52242 United States | University of Iowa | December 6, 2019 - October 2020 |
| NCT04025554 | Anakinra for the Treatment of Chronically Inflamed White Matter Lesions in Multiple Sclerosis | Recruiting | Interventional | National Institutes of Health Clinical Center Bethesda Maryland 20892 United States | National Institutes of Health Clinical Center (CC) | October 25, 2019 - January 31, 2022 |
| NCT04033133 | Cerebral Blood Flow and tDCS | Recruiting | Interventional | Department of Health and Human Physiology Iowa City Iowa 52242 United States | University of Iowa | December 20, 2019 - August 15, 2020 |
| NCT04035005 | A Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis | Recruiting | Interventional | Phoenix Neurological Associates Ltd Phoenix Arizona 85006 United States | Hoffmann-La Roche | August 12, 2019 - April 4, 2028 |
| NCT04038541 | Prebiotic vs Probiotic in Multiple Sclerosis | Recruiting | Interventional | Columbia University Medical Center New York New York 10032 United States | Columbia University | March 11, 2020 - December 2021 |
| NCT04047628 | Best Available Therapy Versus Autologous Hematopoetic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS) | Recruiting | Interventional | Stanford Multiple Sclerosis Center Palo Alto California 94304 United States | National Institute of Allergy and Infectious Diseases (NIAID) | December 19, 2019 - October 2029 |
| NCT04048577 | A Pilot Study to Characterize the Biological Effect of a Pre-planned 12 Week Dose Interruption of Natalizumab | Recruiting | Interventional | Regina Berkovich MD, PhD Inc. West Hollywood California 90048 United States | Berkovich, Regina MD, PhD Inc. | July 3, 2019 - March 1, 2021 |
| NCT04073940 | Exploration of Brain Changes Due to a Targeted Ballet Program in Multiple Sclerosis | Recruiting | Interventional | University of Illinois at Urbana-Champaign Champaign Illinois 61820 United States | University of Illinois at Urbana-Champaign | August 29, 2019 - January 15, 2021 |
| NCT04075266 | A Study of Ocrelizumab in Children and Adolescents With Relapsing-Remitting Multiple Sclerosis | Recruiting | Interventional | Loma Linda University health Loma Linda California 92354 United States | Hoffmann-La Roche | January 9, 2020 - August 12, 2025 |
| NCT04082468 | VALIDATE: Factor VIII Trending for MS Relapse | Recruiting | Observational | Barrow Neurological Institute Phoenix Arizona 85013 United States | St. Joseph's Hospital and Medical Center, Phoenix | August 13, 2019 - March 1, 2022 |
| NCT04091464 | TRAIN-BW: Backward Walking Training in Multiple Sclerosis | Recruiting | Interventional | Wayne State University Detroit Michigan 48201 United States | Wayne State University | January 1, 2020 - December 31, 2022 |
| NCT04096443 | Oral FMT (Fecal Microbial Transplant) in Subjects With Multiple Sclerosis | Recruiting | Interventional | Griffin Hospital Derby Connecticut 06418 United States | Griffin Hospital | October 28, 2019 - September 30, 2020 |
| NCT04114994 | Longitudinal Cognitive Assessment by BoCA | Recruiting | Observational | Andrey Vyshedskiy Miami Florida 33156 United States | Alzheimer's Light LLC | October 1, 2019 - October 1, 2029 |
| NCT04122989 | Validation of a Shared Decision-Making Tool for Multiple Sclerosis | Recruiting | Interventional | Shared Decision Making Resources Georgetown Maine 04548 United States | Shared Decision Making Resources | November 12, 2019 - December 30, 2021 |
| NCT04140305 | Study Describing Cognitive Processing Speed Changes in Relapsing Multiple Sclerosis Subjects Treated With Ozanimod (RPC-1063) | Recruiting | Interventional | Neurological Institute of Alabama Birmingham Alabama 35209 United States | Celgene | January 16, 2020 - June 28, 2025 |
| NCT04141891 | Advancing Understanding of Transportation Options | Recruiting | Interventional | University of California, San Diego La Jolla California 92037 United States | University of Colorado, Denver | December 12, 2019 - August 1, 2023 |
| NCT04144257 | Role of Microglial Activation and Norepinephrine Transporter Abnormalities in Pathogenesis of MS-related Fatigue | Not yet recruiting | Interventional | Partners MS Center, 60 Fenwood Road Boston Massachusetts 02115 United States | Brigham and Women's Hospital | October 2019 - September 30, 2020 |
| NCT04145934 | A Randomized Controlled Trial of a Multicomponent Walking Aid Program for People With MS | Recruiting | Interventional | Oregon Health and Science University Portland Oregon 97239 United States | Oregon Health and Science University | February 6, 2020 - December 2021 |
| NCT04148313 | A Pilot Study to Explore the Role of Gut Flora in Multiple Sclerosis | Recruiting | Observational | ProgenaBiome Ventura California 93003 United States | ProgenaBiome | March 2, 2020 - July 2023 |
| NCT04175834 | Comparing Risk and Severity of IRRs in Patients Premedicated With Cetirizine vs. Diphenhydramine Prior to Ocrelizumab | Recruiting | Interventional | Providence Neurological Specialties West Portland Oregon 97225 United States | Providence Health & Services | February 5, 2020 - June 2022 |
| NCT04178005 | Cladribine Tablets After Treatment With Natalizumab (CLADRINA) | Recruiting | Interventional | UT Southwestern Medical center Dallas Texas 75390 United States | University of Texas Southwestern Medical Center | February 19, 2020 - December 2022 |
| NCT04248725 | Telehealth Pain Self-Management for Employed Adults | Recruiting | Interventional | University of Washington Seattle Washington 98104 United States | University of Washington | March 2, 2020 - September 1, 2023 |
| NCT04255953 | Development of a Telehealth Obesity Intervention for Patients With MS: Modifying Diet and Exercise in MS | Recruiting | Interventional | University of Missouri-Kansas City Kansas City Missouri 64110 United States | University of Missouri, Kansas City | August 1, 2020 - October 2024 |
| NCT04257071 | Out of Pocket Cost Communication in Multiple Sclerosis Patients | Recruiting | Interventional | Neurology Clinic, 12 Executive Park Drive Atlanta Georgia 30329 United States | Emory University | March 3, 2020 - December 2021 |
| NCT04267926 | MitoQ for Fatigue in Multiple Sclerosis (MS) | Recruiting | Interventional | VA Portland Health Care System, Portland, OR Portland Oregon 97239 United States | VA Office of Research and Development | April 1, 2020 - November 30, 2023 |
| NCT04300816 | Coping and Adjusting to Living With Multiple Sclerosis | Recruiting | Interventional | University of Washington Seattle Washington 98195 United States | University of Washington | October 30, 2019 - March 31, 2023 |
| NCT04306939 | Genomic Resources for Enhancing Available Therapies (GREAT1.0) Study | Recruiting | Observational | University of Pittsburgh Medical Center Pittsburgh Pennsylvania 15213 United States | University of Pittsburgh | November 1, 2014 - December 1, 2025 |
| NCT04314076 | Rhythmic Auditory Stimulation & Gait Training | Recruiting | Interventional | Cleveland Clinic Cleveland Ohio 44195 United States | The Cleveland Clinic | June 8, 2020 - December 31, 2022 |
| NCT04322149 | Multiple Doses of AT-1501-A201 in Adults With ALS | Recruiting | Interventional | Barrows Neurological Institute Phoenix Arizona 85013 United States | Eledon Pharmaceuticals | October 16, 2020 - October 2021 |
| NCT04338022 | Study of Evobrutinib in Participants With RMS (evolutionRMS 1) | Recruiting | Interventional | Research Site 629 Mobile Alabama 36693-7003 United States | Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany | June 12, 2020 - July 10, 2026 |
| NCT04338061 | Study of Evobrutinib in Participants With RMS (evolutionRMS 2) | Recruiting | Interventional | Research Site 752 Cullman Alabama 35058 United States | Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany | July 2, 2020 - July 10, 2026 |
| NCT04353492 | An Open-label Study Evaluating Ofatumumab Treatment Effectiveness and PROs in Subjects With RMS Transitioning From Dimethyl Fumarate or Fingolimod to Ofatumumab | Recruiting | Interventional | Novartis Investigative Site Cullman Alabama 35058 United States | Novartis | July 14, 2020 - January 6, 2025 |
| NCT04377555 | Prospective Study to Assess Disease Activity and Biomarkers in Minority Participants With Relapsing Multiple Sclerosis (RMS) After Initiation and During Treatment With Ocrelizumab. | Recruiting | Interventional | Barrow Neurological Institute Phoenix Arizona 85013 United States | Genentech, Inc. | July 30, 2020 - May 9, 2024 |
| NCT04387110 | Ocrelizumab in Breastmilk | Recruiting | Observational | University of California, San Francisco San Francisco California 94158 United States | University of California, San Francisco | August 7, 2020 - December 19, 2021 |
| NCT04387734 | Effects of Ocrevus in Relapsing Multiple Sclerosis | Recruiting | Interventional | Georgia State University Atlanta Georgia 30303 United States | Georgia State University | February 5, 2021 - September 2025 |
| NCT04389970 | Time Restricted Eating Outcomes in Multiple Sclerosis | Recruiting | Interventional | University of Alabama at Birmingham Birmingham Alabama 35294 United States | University of Alabama at Birmingham | October 1, 2020 - August 1, 2021 |
| NCT04390009 | Entire-body PET Scans for Multiple Sclerosis | Not yet recruiting | Interventional | Brain Health Alliance Ladera Ranch California 92694 United States | Brain Health Alliance | March 1, 2021 - March 1, 2022 |
| NCT04391023 | Cerebellar tDCS and Balance Training in PwMS | Not yet recruiting | Interventional | University of Iowa Iowa City Iowa 52242 United States | University of Iowa | May 15, 2020 - February 2021 |
| NCT04403594 | Functional Intermuscular Reduction of Spasticity | Recruiting | Observational | Oklahoma Medical Research Foundation Oklahoma City Oklahoma 73104 United States | University of Oklahoma | August 19, 2019 - April 18, 2021 |
| NCT04410978 | Relapsing Forms of Multiple Sclerosis (RMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) | Recruiting | Interventional | Investigational Site Number 8400013 Birmingham Alabama 35233 United States | Sanofi | June 30, 2020 - August 2023 |
| NCT04410991 | Relapsing Forms of Multiple Sclerosis (RMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) | Recruiting | Interventional | Investigational Site Number 8400009 Cullman Alabama 35058 United States | Sanofi | June 11, 2020 - August 2023 |
| NCT04411641 | Nonrelapsing Secondary Progressive Multiple Sclerosis (NRSPMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) | Recruiting | Interventional | Investigational Site Number 8400013 Birmingham Alabama 35233 United States | Sanofi | September 24, 2020 - August 2024 |
| NCT04415372 | Macromolecular Imaging of White and Gray Matter Pathology in Multiple Sclerosis | Recruiting | Observational | University of Wisconsin, Madison Madison Wisconsin 53705 United States | University of Wisconsin, Madison | June 2021 - April 2025 |
| NCT04416243 | Feasibility of a High-intensity Interval Training Program in Persons With Multiple Sclerosis Who Have Walking Disability | Recruiting | Interventional | Berry College Mount Berry Georgia 30149 United States | Berry College | December 19, 2019 - September 30, 2021 |
| NCT04447937 | Immunodeficiency in MS | Not yet recruiting | Observational | Advanced Neurosciences Institute Franklin Tennessee 37064 United States | Advanced Neurosciences Institute | June 29, 2020 - July 30, 2021 |
| NCT04448977 | Examining Effects of Ocrevus on Cognitive Fatigue Using fMRI | Not yet recruiting | Observational | Kessler Foundation West Orange New Jersey 07052 United States | Kessler Foundation | May 2021 - July 2022 |
| NCT04458051 | Primary Progressive Multiple Sclerosis (PPMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) | Recruiting | Interventional | Investigational Site Number 8400070 Arcadia California 91006 United States | Sanofi | August 13, 2020 - August 2024 |
| NCT04459988 | Mechanistic Study of Ocrevus | Recruiting | Observational | University of Michigan Ann Arbor Michigan 48109 United States | University of Michigan | July 1, 2020 - July 2022 |
| NCT04466150 | Impact of Ocrelizumab on Cerebrospinal Fluid Biomarkers at Multiple Sclerosis Onset | Recruiting | Interventional | University of California San Francisco San Francisco California 94158 United States | University of California, San Francisco | August 30, 2020 - December 2025 |
| NCT04466228 | Non-invasive Transcranial Electrical Stimulation in MS | Recruiting | Interventional | UCSF Sandler Neurosciences Center San Francisco California 94158 United States | University of California, San Francisco | October 16, 2020 - October 2021 |
| NCT04486716 | A Single Arm Study Evaluating the Efficacy, Safety and Tolerability of Ofatumumab in Patients With Relapsing Multiple Sclerosis | Recruiting | Interventional | Novartis Investigative Site Birmingham Alabama 35209 United States | Novartis | October 19, 2020 - December 24, 2022 |
| NCT04495556 | Central Vein Sign: a Diagnostic Biomarker in Multiple Sclerosis | Recruiting | Observational | Cedars-Sinai Medical Center Los Angeles California 90048 United States | The Cleveland Clinic | September 11, 2020 - June 2024 |
| NCT04496804 | Examining the Neural Effects of a Behavioral Intervention for Physical Activity in Multiple Sclerosis | Recruiting | Interventional | University of Alabama at Birmingham Birmingham Alabama 35209 United States | University of Alabama at Birmingham | November 2, 2020 - August 2021 |
| NCT04496830 | SPINCOMS Biomarker Study | Recruiting | Interventional | Washington University in St Louis Saint Louis Missouri 63110 United States | Washington University School of Medicine | June 15, 2020 - July 1, 2023 |
| NCT04503187 | Motor Skill Acquisition Between Individuals With Neurological Disorders and Healthy Individuals | Recruiting | Observational | Texas Woman's University Houston Texas 77030 United States | Texas Woman's University | April 4, 2013 - December 31, 2024 |
| NCT04510220 | 9-month Study to Assess the Efficacy of Ofatumumab on Microglia in Patients With Relapsing Forms of Multiple Sclerosis | Not yet recruiting | Interventional | Partners MS Center, 60 Fenwood Road Boston Massachusetts 02115 United States | Brigham and Women's Hospital | August 2020 - December 31, 2021 |
| NCT04530955 | Transitioning to a Valve-Gated Intrathecal Drug Delivery System (IDDS) | Recruiting | Interventional | Culicchia Neurological Clinic Marrero Louisiana 70072 United States | Culicchia Neurological Clinic | September 24, 2020 - June 2023 |
| NCT04539002 | Aerobic Exercise for Remyelination in Multiple Sclerosis | Recruiting | Interventional | Oregon Health & Science University Portland Oregon 97239 United States | Oregon Health and Science University | April 29, 2021 - January 31, 2023 |
| NCT04544436 | A Study to Evaluate the Efficacy, Safety and Pharmacokinetics of a Higher Dose of Ocrelizumab in Adults With Relapsing Multiple Sclerosis (RMS) | Recruiting | Interventional | North Central Neurology Associates Cullman Alabama 35058 United States | Hoffmann-La Roche | November 26, 2020 - August 15, 2028 |
| NCT04544449 | A Study To Evaluate The Efficacy And Safety Of Fenebrutinib Compared With Ocrelizumab In Adult Participants With Primary Progressive Multiple Sclerosis | Recruiting | Interventional | Fullerton Neurology and Headache Center Fullerton California 92835 United States | Hoffmann-La Roche | October 26, 2020 - May 17, 2028 |
| NCT04548154 | Proximal Resistance Training for People With Multiple Sclerosis | Recruiting | Interventional | University of Colorado Aurora Colorado 80045 United States | University of Colorado, Denver | October 12, 2020 - August 2022 |
| NCT04548999 | A Study to Evaluate the Efficacy, Safety and Pharmacokinetics of a Higher Dose of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (PPMS) | Recruiting | Interventional | Alabama Neurology Associates Homewood Alabama 35209 United States | Hoffmann-La Roche | December 3, 2020 - August 8, 2028 |
| NCT04550455 | A Prospective Biomarker Study in Active SPMS Subjects Treated With Cladribine Tablets | Recruiting | Interventional | Multiple Sclerosis Center of Northeastern New York, P.C. Latham New York 12110 United States | Multiple Sclerosis Center of Northeastern New York | September 16, 2020 - December 2025 |
| NCT04552561 | My MS Toolkit + Coaching: A Guided Web-based Symptom Self-Management Program for People With MS | Recruiting | Interventional | The University of Michigan Ann Arbor Michigan 48109 United States | University of Michigan | October 19, 2020 - June 2021 |
| NCT04564495 | Home Based Tele-exercise for People With Chronic Neurological Impairments | Recruiting | Interventional | Burke Neurological Institute White Plains New York 10605 United States | Burke Medical Research Institute | January 22, 2021 - December 31, 2023 |
| NCT04565431 | Examining Effects of Tysabri on Cognitive Fatigue Using fMRI | Not yet recruiting | Observational | Kessler Foundation West Orange New Jersey 07052 United States | Kessler Foundation | March 2021 - July 2022 |
| NCT04574024 | HFP (High-Fiber Supplement) in MS (Multiple Sclerosis) | Not yet recruiting | Interventional | Robert Wood Johnson University Hospital New Brunswick New Jersey 08901 United States | Rutgers, The State University of New Jersey | January 11, 2021 - September 30, 2023 |
| NCT04586010 | A Study To Evaluate The Efficacy And Safety Of Fenebrutinib Compared With Teriflunomide In Relapsing Multiple Sclerosis (RMS) | Recruiting | Interventional | Center for Neurosciences Tucson Arizona 85718 United States | Hoffmann-La Roche | March 17, 2021 - November 10, 2024 |
| NCT04586023 | Study To Evaluate The Efficacy And Safety Of Fenebrutinib Compared With Teriflunomide In Relapsing Multiple Sclerosis (RMS) | Recruiting | Interventional | North Central Neurology Associates Cullman Alabama 35058 United States | Hoffmann-La Roche | March 24, 2021 - November 10, 2024 |
| NCT04593082 | Obesity and Pediatric Multiple Sclerosis | Not yet recruiting | Observational | University of Virginia Charlottesville Virginia 22903 United States | University of Virginia | November 1, 2020 - September 1, 2024 |
| NCT04601233 | Testosterone Treatment for Erectile Dysfunction and Multiple Sclerosis | Not yet recruiting | Interventional | LSU Health Multispecilaity Clinics New Orleans Louisiana 70112 United States | Tulane University | August 2021 - January 31, 2022 |
| NCT04602390 | Assessment of ANK-700 in Patients With Relapsing Remitting Multiple Sclerosis | Recruiting | Interventional | UC Health Neurosciences Center Aurora Colorado 80045 United States | Anokion SA | November 6, 2020 - December 2023 |
| NCT04603196 | Prevalence and Impact of Obstructive Sleep Apnea in Multiple Sclerosis | Recruiting | Observational | Beth Israel Deaconess Medical Center Boston Massachusetts 02215 United States | Beth Israel Deaconess Medical Center | June 20, 2019 - June 20, 2023 |
| NCT04633759 | Low Load Resistance Training Using Blood Flow Restriction for People With Multiple Sclerosis | Recruiting | Interventional | University of Colorado Aurora Colorado 80045 United States | University of Colorado, Denver | February 19, 2021 - December 31, 2021 |
| NCT04634994 | Novel Assessment of Synaptic Density in Progressive MS | Recruiting | Interventional | Brigham and Women's Hospital Boston Massachusetts 02115 United States | Brigham and Women's Hospital | February 2021 - February 2022 |
| NCT04650321 | Home Based Infusions for Ocrelizumab | Recruiting | Interventional | Amerita Centennial Colorado 80112 United States | University of Colorado, Denver | March 1, 2021 - August 31, 2021 |
| NCT04662008 | Offering Support and Electronic Resources for Care Partners of Those With Multiple Sclerosis | Recruiting | Interventional | Case Western Reserve University Cleveland Ohio 44124 United States | Case Western Reserve University | March 10, 2021 - October 31, 2021 |
| NCT04667117 | A Multicenter Study to Assess Response to Influenza Vaccine in Multiple Sclerosis Participants Treated With Ofatumumab | Recruiting | Interventional | Novartis Investigative Site Phoenix Arizona 85018 United States | Novartis | January 14, 2021 - October 19, 2021 |
| NCT04676555 | Time and Motion Study for Ocrelizumab and Ofatumumab Administration in Relapsing Multiple Sclerosis | Recruiting | Observational | Novartis Investigative Site Gary Indiana 46402 United States | Novartis | May 11, 2021 - December 21, 2021 |
| NCT04682548 | Estimating Prevalence of COVID-19 Infection and SARS-CoV-2 Antibodies in MS Patients | Recruiting | Observational | NYU Langone Health New York New York 10016 United States | NYU Langone Health | January 5, 2021 - December 2021 |
| NCT04688710 | Use of Audio Recordings of Self-Hypnosis and Meditation for Fatigue Management in Multiple Sclerosis | Recruiting | Interventional | UW Medicine Multiple Sclerosis Center Seattle Washington 98133 United States | University of Washington | April 30, 2021 - January 31, 2023 |
| NCT04699747 | Investigating the Utility of Demyelination Tracer [18F]3F4AP in Controls and Multiple Sclerosis Subjects | Recruiting | Interventional | Massachusetts General Hospital Boston Massachusetts 02114 United States | Massachusetts General Hospital | March 25, 2021 - November 30, 2024 |
| NCT04711148 | A Phase 2 Study of Orelabrutinib in Patients With Relapsing-Remitting Multiple Sclerosis | Recruiting | Interventional | Neurology Associates of Ormond Beach Ormond Beach Florida 32174 United States | Beijing InnoCare Pharma Tech Co., Ltd. | March 1, 2021 - March 1, 2024 |
| NCT04735406 | The MS-LINK™ Outcomes Study | Recruiting | Observational | Georgetown University Washington District of Columbia 20057 United States | EMD Serono | March 24, 2021 - January 31, 2024 |
| NCT04742400 | Tolebrutinib, a Brain-penetrant Bruton s Tyrosine Kinase Inhibitor, for the Modulation of Chronically Inflamed White Matter Lesions in Multiple Sclerosis | Recruiting | Interventional | National Institutes of Health Clinical Center Bethesda Maryland 20892 United States | National Institutes of Health Clinical Center (CC) | April 15, 2021 - December 31, 2022 |
| NCT04754542 | Discontinuation of Disease Modifying Therapies (DMTs) in Multiple Sclerosis (MS): Extension of the DISCOMS Study | Recruiting | Observational | University of Colorado Denver Aurora Colorado 80045 United States | University of Colorado, Denver | May 18, 2021 - August 2022 |
| NCT04764383 | Histaminergic Basis of Fatigue in Multiple Sclerosis | Not yet recruiting | Interventional | University of Miami Miami Florida 33136 United States | University of Miami | January 1, 2022 - October 30, 2022 |
| NCT04782466 | ATOMIC (Active Teens Multiple Sclerosis) Physical Activity Research Program | Recruiting | Interventional | The University of Alabama at Birmingham Birmingham Alabama 35294 United States | The Hospital for Sick Children | December 1, 2020 - September 2023 |
| NCT04789551 | T Cell Profiling in Patients With Multiple Sclerosis | Not yet recruiting | Observational | Boston Children's Hopsital Boston Massachusetts 02115 United States | Boston Children's Hospital | July 1, 2021 - December 1, 2022 |
| NCT04796584 | Efficacy of COVID-19 Vaccination in Patients With Multiple Sclerosis Treated With Immune Modulating Medication | Recruiting | Observational | Providence Neurological Specialties West Portland Oregon 97225 United States | Providence Health & Services | March 18, 2021 - June 17, 2022 |
| NCT04834401 | Effect of Disease Modifying Therapy on Antibody Response to COVID19 Vaccination in Multiple Sclerosis | Recruiting | Observational | Saint Barnabas Medical Center Livingston New Jersey 07039 United States | St. Barnabas Medical Center | March 22, 2021 - April 15, 2023 |
| NCT04837651 | Comparing the Antibody Response to COVID-19 Vaccination in Multiple Sclerosis Patients Treated With Ocrelizumab or Natalizumab | Recruiting | Observational | Dragonfly Research, LLC Wellesley Massachusetts 02481 United States | Dragonfly Research, LLC | March 8, 2021 - September 8, 2022 |
| NCT04843774 | Vaccine-generated Immunity in Ocrelizumab-treated Patients: Longitudinal Assessments (VIOLA) | Recruiting | Observational | University of Colorado, Denver (UCD) Denver Colorado 80204 United States | NYU Langone Health | April 20, 2021 - October 14, 2022 |
| NCT04843813 | Effects of Lutein Supplementation on Cognition and MPOD in Multiple Sclerosis Patients- | Recruiting | Interventional | University of Illinois at Urbana-Champaign Urbana Illinois 61801 United States | University of Illinois at Urbana-Champaign | March 26, 2021 - March 2023 |
| NCT04855825 | Investigating the Effects of Wearable Robotic Exoskeleton for Improving Mobility and Cognition in Persons With MS | Recruiting | Interventional | Kessler Foundation West Orange New Jersey 07052 United States | Kessler Foundation | October 5, 2017 - December 30, 2021 |
| NCT04857489 | Deficient T Regulatory Cell (Treg) Function in Patients With Relapsing Remitting Multiple Sclerosis | Recruiting | Observational | Thomas Jefferson University Philadelphia Pennsylvania 19107 United States | Thomas Jefferson University | June 1, 2020 - June 2023 |
| NCT04885894 | An Examination of Cognitive Fatigue Using Functional Neuroimaging | Not yet recruiting | Observational | Kessler Foundation West Orange New Jersey 07052 United States | Kessler Foundation | September 2021 - August 2023 |
| NCT04893590 | Adapting mHealth Technology to Improve Patient Activation | Recruiting | Interventional | Washington University School of Medicine Saint Louis Missouri 63108 United States | Washington University School of Medicine | May 14, 2021 - February 28, 2022 |
| NCT04906057 | The Therapeutic Effects of Forced Aerobic Exercise in Multiple Sclerosis | Recruiting | Interventional | Cleveland Clinic Main Campus Cleveland Ohio 44195 United States | The Cleveland Clinic | June 2021 - December 1, 2023 |
| NCT04907305 | Next-Gen MS: Feed-forward PRO Data for MS Research | Not yet recruiting | Observational | Research Site Rockland Massachusetts 02370 United States | EMD Serono | July 30, 2021 - October 28, 2024 |
| NCT04942938 | Impact of Direct Current Electrical Stimulation on Spasticity Levels and Functional Muscle Use in MS | Not yet recruiting | Interventional | Centura Health at Home Littleton Colorado 80027 United States | Centura Health | June 20, 2021 - December 1, 2022 |
| NCT04943289 | Intrathecal Administration of DUOC-01 in Adults With Primary Progressive Multiple Sclerosis | Not yet recruiting | Interventional | Duke University Medical Center Durham North Carolina 27705 United States | Duke University | August 30, 2021 - August 30, 2024 |